Camptothecin prodrug

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August undefined, 2024

WebJul 12, 2024 · Prodrug–prodrug activation Camptothecin 4 is a topoisomerase I inhibitor that induces S-phase specific cell death. Since its discovery in the 1960's, several camptothecin derivatives and prodrugs have been reported with the aim of overcoming the drawbacks associated with camptothecin such as solubility and the stability of the … WebSep 11, 2007 · Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme …

Synthesis and activity of a folate peptide camptothecin prodrug

WebDec 31, 2024 · In this paper, galactose decorated trimethyl chitosan (GT)–camptothecin (CPT) prodrug nanoparticles (GT-ss-CPT NPs) were prepared from GT-CPT conjugates linked by dithiodipropionic acid. The obtained GT-ss-CPT NPs were spherical with a particle size of 184.1 nm. GT-ss-CPT NPs displayed low drug release under physiological … WebHerein, we fabricated a novel amphiphilic lactose-camptothecin prodrug molecular Lac-SS-CPT which can self-assemble into Lac-SS-CPT glyco-nano prodrug system for GSH … phillip rentals

Prodrugs: design and clinical applications - Nature

WebIrinotecan is a prodrug designed to deliver the poorly soluble parent molecule SN-38, an analog of a highly potent plant alkaloid camptothecin (CPT). Camptothecin and its analogs inhibit the nuclear enzyme topoisomerase I, inhibiting replication and demonstrating antitumor activity as an S-phase-specific drug ( Garcia-Carbonero and Supko, 2002 ). WebOct 21, 2024 · A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activations. Mitochondria are crucial regulators of the … WebAbstract A folate receptor targeted camptothecin prodrug was synthesized using a hydrophilic peptide spacer linked to folate via a releasable disulfide carbonate linker. The conjugate was found to possess high affinity for folate receptor-expressing cells and inhibited cell proliferation in human KB cells with an IC 50 of 10 nM. try spinning thats a neat trick

Self-assembly delivery system based on small-molecule camptothecin …

Self-Assembled Disulfide Bond Bearing Paclitaxel—Camptothecin Prodrug ...

WebDOI号:文献链接:文献作者:备注信息: Camptothecin-doxorubicin prodrug and its preparation method and application WebSep 20, 2024 · The construction of prodrug and glucose oxidase coloaded alginate (ALG) hydrogels for PDT-combined chemotherapy of melanoma will provide a promising injectable hydrogel platform for effective treatments of cancer. Biomimetic nanoprodrugs from fatty acid modified camptothecin and albumin for enhanced pharmacotherapy. tryspin_varydurationNational Center for Biotechnology Information try spike and buffy

"WebJan 13, 2024 · Therapeutic conjugate approaches that alter the solubility of a conjugate “prodrug” have been used to enable NC formation and controlled release from NCs using labile linker chemistry. A limitation of this approach has been that a different linker chemistry must be used to produce an adjustable release rate for a single therapeutic. " - Camptothecin prodrug

Camptothecin prodrug

WebDec 15, 2024 · In this study, we report the synthesis and biological evaluation of the β-glucuronidase-reactive albumin-binding prodrug Mal-glu-CPTS0001 (Fig. 2 A) [40].The … WebOct 15, 2006 · A folate receptor targeted camptothecin prodrug was synthesized using a hydrophilic peptide spacer linked to folate via a releasable disulfide carbonate …

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WebEster prodrugs are most often used to enhance the lipophilicity, and thus the passive membrane permeability, of water-soluble drugs by masking charged groups such as carboxylic acids and... WebA novel functional reducible camptothecin (CPT) block copolymer conjugate was prepared using atom transfer radical polymerization (ATRP). The use of ATRP in the design and …

WebAug 5, 2024 · Herein, we designed a glutathione (GSH)-responsive camptothecin (CPT) prodrug-based hybrid micellar nanoparticles (siPD-L1@HM-CPT) to achieve … WebKeywords: CPT prodrug, dual responsive, sequential drug release, prostate-specific membrane antigen, ... Li Y, Lin J, Ma J, et al. Methotrexate–camptothecin prodrug nanoassemblies as a versatile nanoplatform for biomodal imaging-guided self-active targeted and synergistic chemotherapy.

Webnoun. camp· to· the· cin ˌkamp-tə-ˈthē-sən. : an alkaloid C20H16N2O4 from the wood of a Chinese tree (Camptotheca acuminata of the family Nyssaceae) that has shown … WebHerein, we fabricated a novel amphiphilic lactose-camptothecin prodrug molecular Lac-SS-CPT which can self-assemble into Lac-SS-CPT glyco-nano prodrug system for GSH responsive and targeted drug co-delivery due to the existence of disulfide bond and lactose. 41–44 Then, the CPT-based glyco-nano prodrug system further provides a suitable ...

WebIntroduction. Camptothecin (CPT) is a naturally occurring alkaloid with potent antineoplastic activity against a broad spectrum of solid tumors (eg, primary and metastatic colon …

WebDec 1, 2024 · To increase drug loading and combination therapy, we covalently conjugated paclitaxel (PTX) and camptothecin (CPT) through a disulfide linker into a prodrug, designated PTX-S-S-CPT. The... phillip reppertWebSep 18, 2024 · MTX and 10-hydroxyl camptothecin (CPT) were chosen to conjugate through ester linkage. Because of the amphiphilicity and ionicity, MTX-CPT conjugates … phillip resnickWebCamptothecin and lactose act as the chemotherapy drug and targeting ligand in the drug delivery system, respectively. Since CPT-S-S-LA is an amphiphilic compound, it can self-assemble into nanoparticles with a diameter of around 110 nm. The CPT-S-S-LA nanoparticles displayed controllable drug release behavior in the physiological environment. phillip respironics.comWebDec 16, 2024 · A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane–naphthalimide fluorescent camptothecin … try spirit by the spirit scripturesWebGlucuronide camptothecin is a type of prodrug produced from camptothecin and glucuronide. Glucuronide, which is also referred to as glucuronoside, is substance produced by linking glucuronic acid to another substance via a glycosidic bond. The prodrug could catalyze and produce the drug camptothecin (CPT), which was discovered in 1966. tryspintra birth controlWebJan 23, 2024 · Bio-(8)-MB-CPT thus exerted strong toxicity towards cervical cancer cells, but unlike the parent drug (camptothecin), showed no toxicity towards normal cells. Moreover, the prodrug displayed significantly enhanced antitumor efficacy in vivo and eradicated the tumor with no obvious side effects (inhibition of the tumor reached up to 99.9 %). phillip respironics.com recallWebFeb 16, 2024 · The aim of this study was to prepare small-molecule camptothecin (CPT) prodrugs and evaluate their effectiveness in colorectal carcinoma therapy. Prodrug nanoparticles (NPs) were physicochemically characterized and evaluated for their cytotoxicity in human colon cancer (HCT116) cell lines. The antitumor efficacy of the NPs … try spirits