WebApr 14, 2024 · Recently Concluded Data & Programmatic Insider Summit March 22 - 25, 2024, Scottsdale Digital OOH Insider Summit February 19 - 22, 2024, La Jolla WebMar 9, 2024 · Conversely, CHX10-Cre might not knockout Bmal1 in RPE cells, because CHX10 is a transcriptional factor localized to the inner nuclear layer, particularly in bipolar cells 22, 23. Thus, it is...
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WebThe Cre-mediated transgene expression in retinal bipolar cells in the Chx10-cre line was not observed by crossing with the reporter mouse line but through Cre-dependent rAAV vector delivery. WebImportantly, Chx10-mediated Cre-recombination of Cav1 significantly reduces Müller glia-specific CAV1 protein while retaining CAV1 protein expression in retinal tissue vasculature. This... inatxrt
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WebJun 18, 2024 · Three cohorts of mice were studied: retinal-specific Bmal1 knockout mice ( Chx10cre − Bmal1fl/fl; hereafter referred to as “ rBmal1 KO” mice) and two control groups: 1) Bmal1fl/fl mice (i.e., littermates of the rBmal1 KO mice expressing only Bmal1fl/fl ); and 2) Chx10cre mice (carrying the eye-specific Chx10-CRE transgene, and to which the … WebFeb 28, 2024 · Transgenic mice expressing Cre recombinase under Best1 [Best1-Cre mice, (Iacovelli et al., 2011)] or Chx10 promoter [Chx10-Cre mice, (Muranishi et al., 2011)] were mated with Hif1a flox/flox mice (Ryan et al., 1998) to obtain RPE or sensory retina specific Hif1a knockout mice, respectively. WebApr 3, 2014 · Several, such as Chx10-Cre and Pax6-αCre, are active only after neurogenesis has been initiated at approximately embryonic day (E)11, and are thus not useful for studying the genetic control of earlier stages of retinal development , . Other lines, such as Dkk3-Cre and Nes-CreER T2, are active in many other CNS regions , . inches of water to gpm calculator