Cisplatin induced cardiotoxicity

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August undefined, 2024

WebMar 21, 2024 · Cisplatin (CP) kills tumour cells by inducing senescence or triggering innate apoptotic pathways that cause irreparable DNA damage, and it is the most commonly used first-line drug for cancer treatment. 1 However, its clinical use is often limited by dose-related cardiotoxicity, 2 which includes arrhythmias, 3 angina pectoris, 4 and cardiac … WebJul 27, 2016 · Take for example the side effects of anticancer treatments: just a few years ago, side effects such as cardiotoxicity and myelotoxicity often forced the interruption of life-saving treatments. ... Callejo and colleagues examined in depth the state of art of cisplatin-induced ototoxicity. In addition to peripheral neurotoxicity, cisplatin ...

Cardiotoxicity of cisplatin-based chemotherapy in …

WebDec 1, 2024 · Cisplatin is a highly effective antitumor agent. However, its use is limited due to severe adverse effects, particularly nephrotoxicity, which occurs in approximately 30% of patients. There is a need for novel renoprotective compounds. WebIn Cisplatin group, cardiac muscle fibers appeared disorganized, disrupted or degenerated with pyknotic nuclei and showed a significant rise in the number of anti-P53 positive nuclei. Significant increments in the percent area of collagenous fibers and TNF-α immune-expression were observed. how did a panzerfaust work

Activation of STING Pathway Contributed to Cisplatin-Induced …

WebLung cancer is a malignant tumor characterized by a rapid proliferation rate, less survivability, high mortality, and metastatic potential. This review focuses on updated research about the clinical application of traditional Chinese medicine (TCM) as an adjuvant therapy to lung cancer treatment and the mechanisms of TCM effect on lung cancer in … WebFeb 6, 2024 · Abstract. The cardiotoxicity of chemotherapeutic drugs as cisplatin has become a major issue in recent years. The present study investigates the efficacy of … WebApr 7, 2024 · This present study investigated the protective effects of asperuloside (ASP) against cadmium-induced nephrocardiac toxicity. Rats were treated with 50 mg/kg of ASP for five weeks and CdCl 2 (5 mg ... how did apartheid affect education

The efficiency of blackberry loaded AgNPs, AuNPs and Ag@AuNPs …

Current Insights into the Management of Late Chemotherapy …

WebAug 17, 2024 · Activation of STING Pathway Contributed to Cisplatin-Induced Cardiac Dysfunction via Promoting the Activation of TNF-α-AP-1 Signal Pathway Front Pharmacol. 2024 Aug 17;12:711238. doi: 10.3389/fphar.2024.711238. eCollection 2024. Authors WebCardiotoxicity has also been linked to cisplatin treatment. The leakages of lactate dehydrogenase (LDH) as well as creatine kinase from the cardiac myocytes result from Cardiotoxicity. 39 This could be secondary processes that results from cisplatin-induced lipid peroxidation or cardiac membranes. how did a. philip randolph dieWebAfter right heart catheterization, pathological results of a myocardial biopsy from the ventricular septum indicated no cardiac muscle hypertrophy, cardiac fibrosis, inflammatory cell infiltration, or myocyte disarray. Eventually, she was diagnosed as having pemetrexed-induced cardiomyopathy. how many satchels for sheet metal wall

"WebCisplatin-induced cardiotoxicity is rare, and the prevalence remains unknown. Jakubowski and Kemeny showed that cardiotoxicity occurs in 6% of the patients … " - Cisplatin induced cardiotoxicity

Cisplatin induced cardiotoxicity

Breast milk mesenchymal stem cells abate cisplatin …

WebMay 9, 2024 · Busulfan-induced pulmonary injury; Cardiotoxicity of cancer chemotherapy agents other than anthracyclines, HER2-targeted agents, and fluoropyrimidines ... et al. … WebOct 20, 2024 · Study results showed that Cis explored acute cardiotoxicity evidenced by deteriorated cardiac indices, induction of oxidative stress, and inflammation with myocardium histological alterations....

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WebDec 30, 2015 · El-Awady el-SE, Moustafa YM, Abo-Elmatty DM, Radwan A. Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies. Eur Eur J … WebQuercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway Authors Shih-Hao Wang 1 2 , Kun-Ling Tsai 3 4 , Wan-Ching Chou 3 , Hui-Ching Cheng 3 , Yu-Ting Huang 3 , Hsiu-Chung Ou 5 , Yun-Ching Chang 6 Affiliations

WebOct 1, 2024 · Cardiotoxicity of chemotherapy exerts as the main hurdle for prognosis, while whether cisplatin causes severe cardiotoxicity remains largely unknown. Accum … WebCancer therapy can result in cardiac toxicity, such as cardiomyopathy. Cardiotoxicity with chemotherapeutic agents in the form of cardiomyopathy was first described in 1966 in patients receiving anthracyclines. 1 However, cancer treatment–induced arrhythmia (CTIA) has not attracted specific attention until recently. 2.

WebFeb 21, 2024 · Cardiotoxicity of trastuzumab and other HER2-targeted agents; Cisplatin nephrotoxicity; Clinical manifestations, diagnosis, and treatment of anthracycline-induced cardiotoxicity; Drug-induced thrombotic microangiopathy (DITMA) Endocrine therapy … WebJun 1, 2013 · At present, no data is provided explaining the mechanism of NO in cisplatin-induced cardiotoxicity. It has been found that NO and its metabolites, including …

WebAug 17, 2024 · Cisplatin-induced cardiotoxicity has been reported to mainly include arrhythmia, acute myocardial infarction, supraventricular tachycardia, and atrial fibrillation …

WebApr 14, 2024 · While the exact mechanisms underlying the relationship between gut microbiota and chemotherapy-induced cardiotoxicity are not yet fully understood, … how many satchels for tool cupboardWebNational Center for Biotechnology Information how did apartheid differ from segregationWebAug 31, 2024 · However, the mechanism of CDDP-induced cardiotoxicity is poorly understood. Acetyl-l-carnitine (ALCAR) is an antioxidant agent with protective effects against the side effects of various chemotherapeutics. CDDP-induced cardiotoxicity and the protective role of ALCAR were evaluated in this study. how did apartheid hurt south africa\u0027s economyWebHowever, it has a wide variety of side effects such as hepato, gastrointestinal, neuro, nephro, and cardiotoxicity (acute and/or chronic) th … The efficiency of blackberry loaded AgNPs, AuNPs and Ag@AuNPs mediated pectin in the treatment of cisplatin-induced cardiotoxicity in experimental rats how did apartheid government come to powerWebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, a potent chemotherapeutic agent used for treating various types of solid organ tumors, is limited by its serious side effects in clinical application (Yu et al., 2024; Deng et al., 2024). Cisplatin can cause an increase in the expression of NF-κB and TNF-α in the liver and kidney (Park et al., 2024 how many satchels for sheet wall rustWebIt may be induced by factors including direct toxicity, ion imbalance, heart infiltration and, in the case of neuroendocrine tumors, the influence of tumor excretions. Keywords: … how many satchels for stone ceiling rustWebJan 10, 2011 · Abstract. Increased oxidative stress and apoptosis have been implicated in the cardiotoxicity that limits the clinical use of cisplatin as an anti-tumoral drug. Our study … how did apartheid come to an end