Cisplatin p53
WebJul 19, 2024 · Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths primarily due to chemoresistance. Somatic mutation of TP53 (36%) and epidermal growth factor receptor (EGFR; > 30%) are major contributors to cisplatin (CDDP) resistance. Substantial evidence suggests the elevated levels of reactive oxygen species … WebJan 1, 2024 · The p53 and p21 proteins, which are senescence modulators, were upregulated at 48 h after cisplatin treatment ( Fig. 1 E and F). The mRNA levels of senescence-associated secretory phenotype (SASP) factors including interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α were increased in NRK cells at 48 h after …
Cisplatin p53
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WebHistopathological examination of cardiac muscles of all studied groups and immunoassay of P53 and caspase 3 in cardiac tissue were examined to assess apoptosis. Cisplatin has … WebDec 1, 2004 · Tubular damage by cisplatin leads to acute renal failure, which limits its use in cancer therapy. In tubular cells, a primary target for cisplatin is presumably the genomic DNA. However, the pathwa... Role …
Webp53 mediates cisplatin-induced apoptosis in renal proximal tubular cells, and p53 can activate caspase-3 . Related to this, Li et al. described that HRPTEp cells treated with … WebFeb 24, 2003 · Because p53 is induced by cisplatin in HCT116 cells (Fig. 1), it could have accounted for this apoptosis response. Transfection with PMS2 did not increase the apoptosis response to cisplatin. In p73-transfected cells, cisplatin did not stimulate apoptosis caused by the overexpression of p73. This is consistent with the inability of …
WebThe inhibition of p53 by pifithrin-α attenuated the cisplatin-induced kidney injury and up-regulated miR-142-5p expression. We also identified the Sirtuin7 (SIRT7) as a target of miR-142-5p. WebWe also demonstrate that the combination of PRIMA-1 and cisplatin is a promising approach for HCC therapy. Taken together, our data support the premise that targeting the amyloid-state of mutant p53 may be an attractive therapeutic approach for HCC, and highlight PRIMA-1 as a new candidate for combination therapy with cisplatin.
WebJul 31, 2014 · To confirm that p53 acted as a mediator of cisplatin-induced nephrotoxicity, we first assessed renal tubular damage by histology scores following 3 days of cisplatin administration in p53-null mice (p53 −/−). C57BL/6 mice, the most commonly used strain for p53 knockout, are relatively resistant to cisplatin-induced nephrotoxicity compared ...
WebMay 16, 2007 · Cisplatin induces p53 mitochondrial translocation: Effect of pifithrin-α. HCT116 wt cells (pre-treated or not with 10 μM pifithrin-α for 16 h) were treated with 50 μM cisplatin for 30 min or maintained untreated. Then, mitochondrial and cytosolic ( A) or total cell extracts ( B) were obtained. ontario m1 test priceWebFeb 28, 2024 · The p53 signaling pathway is involved in cisplatin-induced acute kidney injury (AKI). Western blot analysis showed that p53 was activated in the kidney ( Figures … ontario machete sheathione waide address springfield ilWebFeb 28, 2024 · Both complexes downregulate p53, except in U138-MG upon treatment with 28, and BCL-2 is downregulated by both complexes in all cells. In U87-MG, cisplatin upregulates PUMA, BAX, and NOXA. However, 28 upregulates NOXA in a more significant way, though BAX is downregulated, whereas PUMA levels remain unaltered. ione wa campingWebActivation and involvement of p53 in cisplatin-induced nephrotoxicity. Cisplatin, a widely used chemotherapy drug, induces acute kidney injury, which limits its use and efficacy in … National Center for Biotechnology Information ontario machinery auctionWebSep 6, 2024 · Cisplatin treatment increased p53 phosphorylation and decreased E-cadherin expression. Administration of MM102 reversed these changes. These data suggest that protection against AKI conferred... ontario made websiteWebMar 7, 2008 · Recent work has suggested a role for p53 in cisplatin-induced renal cell apoptosis and kidney injury; however, the signaling pathway leading to p53 activation and renal apoptosis is unknown. Here we demonstrate an early DNA damage response during cisplatin treatment of renal cells and tissues. ontario machete sawback