WebPreviously, D2HGDH was reported to decrease 2-hydroxyglutarate level in breast carcinoma cells, but no other report has examined D2HGDH in breast carcinoma, and … WebMay 23, 2011 · A recent report identified heterozygous germline IDH2 mutations in patients with idiopathic D-2-hydroxyglutaric aciduria, carrying no mutations in D2HGDH and consistently increased D-2HG levels in body fluids [23]; interestingly, the patient did not develop brain tumours.
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial ... - …
WebSep 28, 2016 · D2HGDH-GAL3ST2 was preferentially detected in prostate cancer samples, and seems to be enriched in African American patient samples. A. 16 fusion RNA … WebJan 16, 2024 · The colonic expression of D2HGDH is decreased in ulcerative colitis (UC) patients at baseline who progress to cancer. Hypoxia-inducible factor (Hif)-1α is a key … emt to figherfiter promotional exam
The oncometabolite 2-hydroxyglutarate produced by mutant …
WebAug 19, 2024 · Phenotypic Information for D2HGDH(metabolism pathway, cancer, disease, phenome) Cancer Description: Cancer : CGAP: D2HGDH : Familial Cancer Database: D2HGDH * This gene is included in those cancer gene databases.. Oncogene 1. Tumor Suppressor gene 2. Cancer Gene Census 3. CancerGenes 4. WebApr 4, 2015 · D2HGDH overexpression reduces D-2-HG level in IDH -mutated cancer cells Previous studies using cell permeable D-2-HG analogs or mutant IDH inhibitors have the limitation of possible nonspecific effects associated with all pharmacological agents. WebD2HGDH Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, D2HGDH Genome Browser, D2HGDH References D2HGDH - Explore an overview of … dr. beate thalheimer