WebMoreover, data generated with HET-CAM and SkinEthic™ HCE EIT has been adopted in the integrated approaches to testing and assessment (IATA) and/or defined approaches (DA) for accurate classification of all 3 GHS categories of chemicals for eye irritation/serious eye damage (Alépée et al., 2024a, Alépée et al., 2024b; OECD, 2024a, … WebMay 3, 2024 · IATA development for eye irritation and corrosion has progressed very much in parallel to skin irritation and corrosion with the difference that there is less agreement whether and how the different NAMs in combination can avoid animal testing. The different OECD methods are broadly accepted to identify either non-irritant or corrosive but for ...
Development of a defined approach for eye irritation or serious eye ...
WebJan 18, 2024 · The test accuracy of the best serious eye damage model and eye irritation model reached 0.972 and 0.959, respectively. The applicability domains for all models were calculated to verify the ... WebThe Ocular Irritection test method addresses the eye irritation and serious eye damage endpoint. ... (IATA). This IATA would be similar to the already validated one for skin irritation and corrosion. If validated—e.g., at the OECD—this ocular toxicity strategy may be included in a revised version of the "REACH Guidance on Information ... team heimat frei 3
Ocular irritation assay - Episkin
Web(eye irritation) can be concluded only with a weight-of-evi-dence approach. Thus, the decision process within the IATA for serious eye damage and eye irritation IATA … WebFeb 26, 2024 · In the general hazard properties of class 5.2 organic peroxides IMDG Code mentions “cause damage to the eyes”. Further it observes “ contact of organic peroxides with the eyes is to be avoided. Some organic peroxides will cause serious injury to the cornea, even after brief contact, or will be corrosive to the skin.”. WebH315 Causes skin irritation. H319 Causes serious eye irritation. H335 May cause respiratory irritation. Precautionary statement(s) P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray. P264 Wash skin thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/ eye protection/ face protection. team heimat twitter