WebThe FLVCR1 gene encodes for two different isoforms which allows heme export through the plasma membrane (FLVCR1a) or out of mitochondria (FLVCR1b) in every cell type … WebIntegrative genetic analysis identifies FLVCR1 as an essential component of choline transport in mammals - Genome-wide association studies (GWAS) of serum metabolites have the potential to uncover genes that influence human metabolism. Here, we combined an integrative genetic analysis . bioRxiv. Integrative ...
Mutations in the Heme Exporter FLVCR1 Cause Sensory ... - PLOS
WebFeb 15, 2024 · FLVCR1-AS1 acted as an oncogene in GC via FLVCR1-AS1-miR-155-c-Myc signaling and may serve as a novel therapeutic target for treatment of patients with GC. … WebMar 13, 2024 · Recently, mutations in FLVCR1 have been identified in several human diseases, 42, 43 but the detailed pathogenesis remains unclear. On the basis of our … bkr6es cross reference
Genome-wide metabolite quantitative trait loci analysis (mQTL) in …
WebApr 18, 2024 · Moreover, this work revealed previously uncharacterized roles of FLVCR1 as a new choline transporter; CHEK1 as a post-translational regulator of the PC-synthetic pathway, and TMEM30A as responsible for translocation of PC to the outside of the plasma membrane bilayer. WebMar 21, 2024 · FLVCR1-DT (FLVCR1 Divergent Transcript) is an RNA Gene, and is affiliated with the lncRNA class. Additional gene information for FLVCR1-DT Gene HGNC (39077) NCBI Entrez Gene (642946) Ensembl (ENSG00000198468) OMIM® (610864) UniProtKB/Swiss-Prot (Q8TAF5) Open Targets Platform (ENSG00000198468) Alliance … WebJan 5, 2024 · FLVCR1b regulates erythropoiesis by controlling mitochondrial heme efflux, whereas FLVCR1a expression is required to prevent hemorrhages and edema. FLVCR1 … bkr5e spark plug cross over