WebDec 7, 2024 · Heme (iron protoporphyrin IX) is a major toxic component of hemoglobin released from red cell turnover especially during intravascular hemolysis such as in sickle cell disease, malaria and paroxysmal nocturnal hemoglobinuria. WebNM_017791.3(FLVCR2):c.543G>A (p.Val181=) AND not provided Clinical significance: Benign (Last evaluated: Nov 1, 2024) Review status: 2 stars out of maximum of 4 stars
NM_017791.3(FLVCR2):c.648C>G (p.Ser216=) AND Posterior …
WebJan 15, 2024 · Heme, an iron-containing porphyrin, is of vital importance for cells due to its involvement in several biological processes, including oxygen transport, energy production and drug metabolism. ... The role of FLVCR2 in normal cells is not well-studied and to our knowledge there is only one paper to date in which FLVCR2 was analyzed in cancer. WebApr 20, 2024 · Altogether, these observations suggest that upregulation of other acute phase proteins during exercise training, such as Hpx, haptoglobin, and Flvcr2, can bind and transport heme to be metabolized by HO-1 intracellularly (Alonso et al., 2024; Schaer et al., 2014). For instance, in the absence of HO-1, but not Hpx, heme is highly toxic and ... immunohistological analysis
pitx1 related genes - GeneCards Search Results
WebMar 21, 2024 · FLVCR2 (FLVCR Heme Transporter 2) is a Protein Coding gene. Diseases associated with FLVCR2 include Proliferative Vasculopathy And Hydranencephaly … WebOct 12, 2024 · The prognostic marker FLVCR2 associated with tumor progression and immune infiltration for acute myeloid leukemia Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies in adults. The tumor microenvironment (TME) has a critical effect on AML occurrence, recurrence, and progression. WebApr 1, 2013 · FLVCR2 is highly homologous to FLVCR1 and may function as a cellular heme importer. Mutations of SLC49A2 encoding FLVCR2 are observed in Fowler syndrome, a rare proliferative vascular disorder of the brain. The functions of the remaining members of the SLC49 family, MFSD7 and DIRC2 (encoded by the SLC49A3 and … list of wars and anthropogenic disasters