WebIU1 is a cell-permeable, reversible and selective proteasome inhibitor of human USP14 with IC50 of 4.7 μ M, 25-fold selective to IsoT. IU1 induces autophagy. CAS No. 314245-33-5 … Web10 de jun. de 2015 · After 48 h, cells were treated with DMSO, 50 μg/ml CHX alone, or a combination of CHX and 100 μM IU1 for 6 h. Lysates were analyzed by immunoblotting …
IU1 suppresses proliferation of cervical cancer cells through …
Web24 de nov. de 2024 · We previously found that a small-molecule inhibitor of USP14, known as IU1, can increase the rate of degradation of a subset of proteasome substrates. We report here the synthesis and characterization of 87 variants of IU1, which resulted in the identification of a 10-fold more potent USP14 inhibitor that retains specificity for USP14. Web27 de mar. de 2024 · In accordance with these findings, IU1 treatment decreased G2/M-phase cell-cycle regulatory proteins’ cell-division cycle 25C (CDC25C) and its downstream protein CDC2, as well as cyclin B1 ( Figure 3 A). We also examined the effect of IU1 on G1/S-phase marker proteins, including cyclin E1, cyclin D1, and p21. greater good warhammer 40k
Inhibition of USP14 Deubiquitinating Activity as a Potential …
WebMovie Info. Two young entrepreneurs set out on a hash-fueled journey across Atlanta seeking funds for their on-demand munchies delivery business. Rating: TV14. Genre: … WebBars: 10 μ m. (f) During 48 h of IU1 treatment and 12 h prior to harvest, N2a58 cells were treated with DMSO or MG132 (1, 2.5, 5 μ M). Lysates were analyzed by immunoblotting with anti-PrP ... WebRight ventricular failure (RVF) after left ventricular assist device (LVAD) implantation is associated with increased morbidity and mortality, but the identification of LVAD candidates at risk for RVF remains challenging. We undertook a systematic review and meta-analysis of observational studies of … greater good utilitarianism