ABO incompatibility occurs by the same general mechanism. Type O mothers are most commonly impacted, since they carry both anti-A and anti-B antibodies. If the infant is type A, type B, or type AB, risk for incompatibility … See more The two most commonly recognized forms of antibody-mediated hemolysis in newborns are Rh incompatibility and ABO incompatibility. Rh … See more Conversely, active hemolysis may be present with a negative coombs' test. Conditions that cause the rbc to be inherently defective in some way (hereditary … See more An important thing to remember is that the presence of a positive coombs' test in the lab does not necessarily result in hyperbilirubinemia in the infant. The risk of needing phototherapy is certainly greater, but there are many … See more If the antibody identified is clinically significant, then the pathophysiology is the same as for Rh or ABO incompatibility. If mixing of maternal and fetal blood occurs during pregnancy or the birth process, maternal antibodies … See more WebAug 3, 2013 · Physicochemical incompatibility can have serious clinical consequences and cause many complications, such as catheter obstruction, loss of drug efficacy, formation of toxic derivatives or the occurrence of embolism. Fatalities resulting from drug incompatibilities have been reported. (5,6) Preventing drug incompatibilities

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