WebSee Taconic Bioscience’s Constitutive Knock Out mouse, model # Gpr183. Toggle navigation. ... For most lines, the mouse ES cells used in generating the model are of the … WebNov 11, 2024 · Knockout or knockdown of OTUD4 impairs RNA virus-triggered activation of IRF3 and NF-κB, expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo. Consistently, Cre-ER Otud4fl/fl or Lyz2-Cre Otud4fl/fl mice produce decreased levels of type I interferons and proinflammatory cytokines and exhibit ...
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WebNov 6, 2024 · (c) Top left, schematic of a parabiosis experiment in which Irf3 −/− mice were subjected to MI after they had been paired to either Irf3 −/− (KO→KO) or WT (WT→KO) mice. Top right ... WebFeb 11, 2024 · Adipocyte-specific knockout of Irf3 attenuates HFD-induced obesity in mice and increases insulin sensitivity. To assess the metabolic consequences of IRF3 … data analyst investigo
Pathogen Specific, IRF3-Dependent Signaling and Innate ... - PLOS
WebIRF3 −/− mice 38 were a generous gift from Tadatsugu Taniguchi and provided by Michael Diamond. IFNAR knockout mice (IFNAR −/−) were originally from J. Sprent and were backcrossed for 12 generations at the University of Massachusetts Medical School and provided by Kate Fitzgerald. Genotyping was performed in-house using methods ... WebMar 4, 2024 · Knockdown of USP22 inhibits IRF3 nuclear accumulation in human cell lines To determine whether USP22 is a physiological regulator for IRF3, we designed three siRNAs targeting USP22, two of which potently down-regulated the protein levels of ectopic and endogenous USP22 ( Fig. 2 A ). WebOct 17, 2013 · In this report we demonstrate that replication of the TMEV RNA genome is significantly higher in macrophages from IRF3 knockout (IRF3KO) mice and in the brains of IRF3KO mice following intracranial infection compared with B6 mice. IRF3 deficiency caused greater morbidity and mortality during intracranial TMEV GDVII infection, less TMEV … data analyst interview tips