WebJun 11, 2024 · Klotho is a natural protein enzyme that exists within the body and brain. This protein is created by the KL gene and is produced in the kidneys. It appears to have a large role in the regulation of phosphate, but this is only a small portion of the significance of Klotho. Klotho is currently making headlines because it's been linked to anti ... WebOct 1, 2024 · In various tumor types, Klotho downregulation promotes cell proliferation and reduces cancer cell apoptosis. Soluble Klotho reduces tumor growth in vitro and in vivo in …
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WebMar 12, 2024 · α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious changes with ageing and disease. Declines in α-Klotho play a role in the pathophysiology of multiple diseases and age-related phenotypes. Pre-clinical evidence suggests that boosting α-Klotho holds therapeutic potential. WebOct 1, 2015 · In humans, α-Klotho deficiency or functional variants of α-Klotho are associated with the development of vascular calcification (11, 17), atherosclerosis , diabetes , hypertension , chronic kidney disease , osteoporosis , anemia , and various cancers such as hepatocellular carcinoma , breast cancer , gastric cancer , and renal cell carcinoma .
WebApr 12, 2024 · Transcription factors (e.g., Smad3 and NF-κB) downregulate Klotho and PGC-1α expression, whereas PGC-1α expression is promoted by histone crotonylation. A comprehensive understanding of these mediators might contribute to the establishment of novel therapeutic approaches towards CKD prevention and progression . The mechanism … WebJul 5, 2011 · We have recently identified klotho as a tumor suppressor in breast cancer. Klotho is expressed in the normal pancreas and both the IGF-I and FGF pathways are …
WebNov 17, 2024 · Klotho Evidence Summary ... cancer. What is it? Klotho (α-Klotho) is located on Chromosome 13, and has been described as an anti-aging gene. It has two major isoforms, a 135 kDa transmembrane protein that serves as an obligatory co-receptor for FGF23, and a 70 kDa secreted form. The transmembrane form is primarily expressed in … WebOct 19, 2024 · The protein Klotho can significantly delay aging, so it has attracted widespread attention. Abnormal downregulation of Klotho has been detected in several aging-related diseases, such as Alzheimer’s disease, kidney injury, cancer, chronic obstructive pulmonary disease (COPD), vascular disease, muscular dystrophy and …
WebJul 1, 2011 · We have recently identified klotho as a tumor suppressor in breast cancer. Klotho is expressed in the normal pancreas and both the IGF-I and FGF pathways are involved in pancreatic cancer development. We, therefore, undertook to study the expression and activity of klotho in pancreatic cancer. Experimental design:
WebMar 19, 2013 · Cancer. Cancer Genetics; Gene Regulation & Cell Proliferation; Signal Transduction; Neuroscience. Swartz Foundation; Stanley Institute for Cognitive Genomics; Genomics; ... Computational Cell Biology: The Interplay Between Models and Experimentation , 2013-3-19 - 2013-3-22 File Citation egg white wonder breadWebJun 12, 2024 · The anti-aging factor, klotho has been identified as a tumor suppressor in various human cancers, including lung cancer. In vitro studies provided evidence that … egg white whipped creamWebMar 1, 2024 · Methylation-specific PCR was performed to assess DNA methylation of Klotho promoter in the peripheral blood leucocytes (PBLs) from CKD patients and obstructive kidney from UUO mice. CCL5, Klotho, and DNA methyltransferases (DNMTs) were determined by ELISAs, immunofluorescence, or western blotting. folding an origami heartWebMay 24, 2024 · This review article focuses on the effects of microRNAs on the performance of Klotho and how the interplay between Klotho and certain pathways like insulin‐like … folding a note 90s styleWebKlotho participates in mineral homeostasis via interplay with other calciophosphoregulatory hormones (parathyroid hormone, fibroblast growth factor-23, and 1,25- [OH]2 vitamin D3) in kidney, bone, intestine, and parathyroid gland. Klotho also may be involved in acute and chronic kidney disease development and progression. folding antenna hingeWebMay 12, 2024 · Fig. 1: Klotho decreases oxygen consumption rate (OCR) in breast cancer cells. a MCF-7 cells were seeded in at a density of 15,000 cells/well and after 24 h were treated with klotho (0.1... folding antenna mastWebThis review article focuses on the effects of microRNAs on the performance of Klotho and how the interplay between Klotho and certain pathways like insulin-like growth factor, … egg white wrap costco