Lxr gene card

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August undefined, 2024

WebFeb 1, 2004 · The nuclear receptors liver X receptor (LXR)α and LXRβ are sensors of cholesterol metabolism and lipid biosynthesis. They have recently been found to be … WebThe liver X receptor (LXR) is a key transcriptional regulator of cholesterol, fatty acid, and phospholipid metabolism. Dynamic remodeling of immunometabolic pathways, including …

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Web1973 TOPPS VINTAGE CARD SIGNED AUTO GENE WASHINGTON MINNESOTA VIKINGS GREAT. $7.99 + $3.50 shipping. 1973 TOPPS GENE WASHINGTON MINNESOTA VIKINGS #359. $4.00. Free shipping. 1973 TOPPS GENE WASHINGTON MINNESOTA VIKINGS #359. $4.00. Free shipping. Picture Information. Picture 1 of 1. … WebMar 21, 2024 · Liver X receptors (LXRs) and farnesoid X receptors (FXRs) are members of the steroid analog-activated nuclear receptor subfamily, which form heterodimers with … community integrated health centralia

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WebApr 28, 2024 · LXR (liver X receptor) deficiency in myeloid cells accelerates the progression of atherosclerosis by increasing monocyte entry, foam cell formation, and plaque inflammation. Bulk cell-RNA profiling of plaque myeloid cells showed an upregulation of inflammatory mediators including oxidative, chemokine, and chemotactic genes. The liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. Additionally, they play an important role in the local activation of thyroid hormones via deiodinases. The inducible LXRα is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ i… WebLiver X Receptor. LXR is a sterol sensor that promotes lipogenesis, whereas PPARα controls a variety of genes in several pathways of lipid metabolism. ... Scd1 is eliminated … community integrated care news

Biological role of liver X receptors - PubMed

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WebFeb 24, 2024 · LXRα and LXRβ (coded for by NR1H3 and NR1H2, respectively) are ligand-activated transcription factors that regulate gene expression (positively and negatively) in a ligand-dependent manner, and that actively control macrophage differentiation and specialization ( 28 – 30 ). WebLXRs bind to the promoters of specific target genes as heterodimers with the retinoid X receptor (RXR; NR2B1). The sequence elements identified by the LXRs are direct repeat four (DR4)-type motifs, termed LXR responsive elements (LXREs; Repa and Mangelsdorf, 2000; Tontonoz and Mangelsdorf, 2003). community integrated care log inWebNational Center for Biotechnology Information community integrated care tullibody

"WebMar 19, 2015 · Apolipoprotein E (APOE) is an LXR target gene that has been implicated in the suppression of metastasis in melanoma models 89. Melanoma cells treated with LXR ligands showed increased APOE... " - Lxr gene card

Lxr gene card

WebLiver X Receptor (LXR)-regulated Genes of Cholesterol Trafficking and Breast Cancer Severity Expression of some LXR-dependent genes is related to breast tumor … WebMar 21, 2024 · Tocris Summary for NR1H2 Gene. Liver X receptors (LXRs) and farnesoid X receptors (FXRs) are members of the steroid analog-activated nuclear receptor … FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with … AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, … PPARGC1A (PPARG Coactivator 1 Alpha) is a Protein Coding gene. Diseases … NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) is a Protein Coding … KMT2C (Lysine Methyltransferase 2C) is a Protein Coding gene. Diseases … APOE (Apolipoprotein E) is a Protein Coding gene. Diseases associated with … CEBPB (CCAAT Enhancer Binding Protein Beta) is a Protein Coding gene. … ABCB1 (ATP Binding Cassette Subfamily B Member 1) is a Protein Coding gene. … NFKB1 (Nuclear Factor Kappa B Subunit 1) is a Protein Coding gene. Diseases … AKT2 (AKT Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases …

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WebNov 15, 2024 · Lipidomic and transcriptomic analysis of in vivo macrophage foam cells demonstrate that desmosterol is a major endogenous liver X receptor (LXR) ligand involved in LXR/retinoid X receptor (RXR) activation and thus macrophage foam cell … WebFeb 2, 2024 · The nuclear receptors liver X receptor (LXR) α and β play crucial roles in hepatic metabolism. Many genes induced in response to pharmacologic LXR agonism have been defined; however, the transcriptional consequences of loss of LXR binding to its genomic targets are less well characterized.

WebLXRbeta is involved in the control of platelet production from megakaryocytes. Liver X Receptor beta Related to Tumor Progression and Ribosome Gene Expression in … WebApr 15, 2011 · The peroxisome proliferator-activated receptor (PPAR)γ and liver X receptor (LXR) nuclear receptors play important roles in both lipid metabolism and inflammation. 1 The endogenous agonists for PPARγ and LXR are fatty acids 2 and oxysterols, 3 respectively, and there is a large body of literature that has established both of these …

WebGene Aliases COSMIC IDs SNP IDs Nucleotide Mutations (e.g. c.2582T>A) Amino Acid Changes (e.g. p.L861Q) RefSeq Accessions. Supported Keywords: Gene symbol Assay ID Plate SKU. Supported Keywords: miRBase ID Assay ID Plate SKU. Supported Keywords: Gene Name Gene ID Assay ID. Supported Keywords: sgRNA IDs Entrez Gene IDs … WebJun 7, 2013 · Liver X receptor (LXR) activation improves glucose homeostasis in obesity. This improvement, however, is associated with several side effects including hyperlipidemia and hepatic steatosis. Activation of peroxisome proliferator-activated receptor alpha (PPARα), on the other hand, increases fatty acid oxidation, leading to a reduction of …

WebMar 19, 2015 · LXRs and LXR ligands have tissue-specific functions and mechanisms, and the heterogeneity of the different types of cancers and the emerging mechanistic …

WebJun 14, 2024 · LXRs bind to and regulate the expression of genes that encode proteins involved in cholesterol absorption, transport, efflux, excretion and conversion to bile … community integrated health services aberdeenWebHow to solve problems with LXR files. Associate the LXR file extension with the correct application. On : Windows: Right click on any LXR file and then click "Open with" > … easyspeed bartoliniWebOct 1, 2009 · Liver X receptor-alpha (LXR-α), being a member of the nuclear receptor/transcription factor family, has been widely recognized to have a pleiotropic effect in the regulation of genes involved in ... easyspeed brtWebLiver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2). [5] community integrated employmentWebThe glucocorticoid receptor (GR) is a crucial target gene for glucocorticoid-induced insulin resistance and hepatic gluconeogenesis linked to the development of type 2 diabetes. The liver X receptors (LXRs) are nuclear receptors that play an important role in the regulation of the metabolic gene linked to carbohydrate homeostasis. easy speech ideasWebLiver X receptor (LXR) α and LXRβ (encoded by Nr1h3 and Nr1h2) play important roles in hepatic lipid metabolism. LXRs are crucial for the lipogenic response to feeding as … easy speech topics for collegeWebDec 3, 2007 · Liver X receptors (LXRs) alpha and ss belong to a family of nuclear receptors which form heterodimers with the retinoid X receptor and, upon ligand binding, stimulate the expression of target genes. LXRs were initially described as orphan receptors and oxidized cholesterol derivatives (oxysterols) were later identified as their natural ligands. easy speed international logistics