Submyeloablative procedures
Web1 May 2013 · Transplantation of hematopoietic stem cells (HSCs) is a potentially curative procedure for a variety of malignant, congenital, and autoimmune diseases. ... Even relatively low submyeloablative doses of gamma radiation damage the trabecular bone and acutely reduce its endosteal surface as demonstrated by increased intertrabecular distances 16, 17. Web16 Nov 2004 · In this study, we sought to determine if donor marrow homing efficiency also correlated with long-term engraftment in these models of submyeloablative conditioning. We hypothesized that sequential doses of the cell cycle-specific agent 5-FU (5-FU x 2) may damage the marrow microenvironment less than low-dose radiation, resulting in more …
Submyeloablative procedures
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Web1 Apr 2010 · We studied in patients with multiple myeloma (MM) the efficacy, cost-effectiveness, and toxicity of a strategy of submyeloablative doses of Mel and stem cell support in the ambulatory setting,... Web16 Nov 2005 · Since graft-vs-tumor effects are the mainstay of sustained disease control after submyeloablative (mini) allogeneic transplantation, rapidly-progressive malignant disease may not be curable with SMAT. ... Since such patients are unlikely to benefit from a standard mini-allograft procedure, they may be better suited for alternatives such as ...
WebMyeloablative conditioning for ALL has generally included total-body irradiation (TBI) or busulfan. Given the ability of TBI-based myeloablative regimens to eradicate the leukemia … Web16 Nov 2006 · The outcome of 30 patients undergoing submyeloablative allogeneic HSCT after 100 mg/m2 (n=24) or 140 mg/m2 (n=6) melphalan was studied to determine the …
Web3 Aug 2024 · The submyeloablative irradiation, employed to establish chimeric hematopoiesis after transplantation of congenic hematopoietic cells, used doses of 3–7 Gy adjusted to the number of transplanted cells. The particular dose of radiation is indicated in the legends to results. Bone Marrow and Spleen Cell Collection WebMyeloablative HSCT most commonly incorporates a BEAM (Carmustine, Cytarabine, Etoposide, Melphalan) chemotherapy protocol. The chemotherapy takes place over six …
Web11 Feb 2009 · The goal of this prospective study is to assess the overall mortality (whether related to relapse/progression or toxicity - TRM-) at one year after allogeneic stem cell …
Web18 Feb 2013 · The damage done to hematopoietic stroma and to the trabecular bone by submyeloablative doses of ionizing radiation does not negatively affect the homing and engraftment mechanisms of intravenously transplanted hematopoietic progenitor and stem cells. ... (HSCs) is a potentially curative procedure for a variety of malignant, congenital, … charm haseWebMyeloablative (high-intensity) stem cell transplant uses high doses of chemotherapy and may use radiation therapy to destroy cancer cells. In this process, bone marrow/stem … charmhaven postcode nswcharmhealth billingWeb16 Nov 2005 · Since such patients are unlikely to benefit from a standard mini-allograft procedure, they may be better suited for alternatives such as conventional-intensity … current news for kingsport times newspaperWeb12 Nov 2024 · Europe PMC is an archive of life sciences journal literature. Search life-sciences literature (Over 39 million articles, preprints and more) current news feedWeb12 Apr 2024 · Myeloablative conditioning (MAC) was used in 20 procedures, and reduced-intensity conditioning (RIC) in 25. Forty-two patients engrafted, two had primary graft failure (one successfully... current news from around the worldWebSubmyeloablative total body irradiation-based conditioning and allogeneic stem cell transplantation in high-risk myeloma with early progression after up-front autologous … charmhealth.com